Korus Ibuprofen

Ibuprofen

Relief of mild to moderate pain including rheumatic & muscular pain, backache, neuralgia, migraine, headache, dental pain, dysmenorrhoea & feverishness.

Adult, elderly, & childn >12 yr 1 or 2 tab tds. Max: 6 tab in 24 hr.

Should be taken with food.

Hypersensitivity to ibuprofen, aspirin, other NSAIDs. Active or previous peptic ulcer. History of upper GI bleeding or perforation, related to previous NSAID therapy. Severe hepatic, renal or heart failure. Pregnancy (3rd trimester). Childn <12 yr.

SLE, mixed connective tissue disease. GI disorders & chronic inflammatory intestinal disease (ulcerative colitis, Crohn's disease). History of HTN &/or heart failure/cardiac impairment, oedema. Renal & hepatic dysfunction. Bronchospasm. Concomitant w/ corticosteroids, warfarin, SSRIs, aspirin. Fructose intolerance. DM. Asthma. Pregnancy (1st & 2nd trimester), lactation. Elderly.

Non-specific allergic reactions, anaphylaxis, resp tract reactivity, pruritus, urticaria, angioedema.

Increased risk of adverse effects w/ aspirin or other NSAIDs & corticosteroids. Decreased effects of antihypertensives & diuretics. Increased risk of nephrotoxicity w/ diuretics & ciclosporin. Enhanced effects of anticoagulants. Increased risk of GI bleeding w/ anti-platelet agents & SSRIs. May exacerbate cardiac failure, reduce GFR & increase plasma glycoside levels w/ cardiac glycosides. Potential increase in lithium & methotrexate plasma levels. Reduced effect of mifepristone. Possible increased risk of nephrotoxicity w/ tacrolimus. Increased risk of haemarthroses & haematoma w/ zidovudine in HIV positive haemophiliacs. Increased risk of convulsions w/ quinolones.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

M01AE01 - ibuprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.

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